If you've got a Cisco Application Content Engine (ACE) to manage, and you rather provide a GUI for some operations or for some users, the Application Network Manager (ANM) is the way to go. Although it does have it's own learning-curve, this is far better than for some users who are not familiar with the MPF (Modular Policy Framework) in the CLI.
ANM has the ability to tie class-maps, policy-maps, rservers, serverfarms, and nat all in one place when defining "virtual servers".
Use ANM when tasks or users are best suited for it. I prefer to deploy new virtual servers through ANM, then manage most everyone else in the CLI.
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